486Meropenem and Piperacillin-tazobactam have Comparable Outcomes in Treatment of Bloodstream Infections Caused by Extended Spectrum Beta-lactamase Producing E.coli and Klebsiellae

نویسندگان

  • Patrick Harris
  • Yin Mo
  • Roland Jureen
  • Jonathan Chew
  • Jaminah Ali
  • David L. Paterson
  • Paul Tambyah
چکیده

in Treatment of Bloodstream Infections Caused by Extended Spectrum Beta-lactamase Producing E.coli and Klebsiellae Patrick Harris; Yin Mo; Roland Jureen; Jonathan Chew; Jaminah Ali; David L. Paterson; Paul Tambyah, MBBS, MD; University of Queensland Centre for Clinical Research, Brisbane, Australia; Division of Infectious Disease, National University Hospital, Singapore, Singapore; Division of Laboratory Medicine, National University Hospital, Singapore, Singapore; International Medical University, Kuala Lumpur, Kuala Lumpur, Malaysia

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Empiric Piperacillin-Tazobactam versus Carbapenems in the Treatment of Bacteraemia Due to Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a common cause of bacteraemia in endemic countries and may be associated with high mortality; carbapenems are considered the drug of choice. Limited data suggest piperacillin-tazobactam could be equally effective. We aimed to compare 30-day mortality of patients treated empirically with piperacillin-tazobactam versus a car...

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Risk factors for and mortality of extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli nosocomial bloodstream infections.

A case-control study, involving patients with positive blood cultures for Klebsiella pneumoniae (KP) or Escherichia coli (EC) EC and controls with positive blood cultures for non-ESBL-KP or EC, was performed to assess risk factors for extended-spectrum-beta-lactamase (ESBL) production from nosocomial bloodstream infections (BSIs). Mortality among patients with BSIs was also assessed. The study ...

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Piperacillin–tazobactam as alternative to carbapenems for ICU patients

Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE)-related infections in non-ICU patients. Little is known concerning ICU patients in whom achieving the desired plasmatic pharmacokinetic/pharmacodynamic (PK/PD) target may be...

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Impact of the MIC of piperacillin-tazobactam on the outcome of patients with bacteremia due to extended-spectrum-β-lactamase-producing Escherichia coli.

We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a MIC of ≤ 2 mg/liter than for isolates with a higher MIC (0% versus 41.1%; P = 0...

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ترکیب آنتی‌بیوتیک‌های بتالاکتام و مهارکننده بتالاکتاماز علیه سویه‌های انتروباکتریاسه تولیدکننده بتالاکتاماز با طیف وسیع

In the last decades, Extended-Spectrum-β-Lactamases (ESBLs) in gram negative bacilli have appeared as a significant mechanism of resistance to antibiotics. Although resistance to carbapenems is increasing among bacteria, they are still the treatment of choice for serious infections caused by ESBL producers. Therefore, the aim of the present study was to evaluate the effect of ß-lacta...

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عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2014